State Street Investment ManagementHealthXBI · NYSE Arca
State Street SPDR S&P Biotech ETF (XBI)
- Price
- $156.20
- —11 Sept 2026
- Assets
- $11.4B
- Total net assets
- Expense ratio
- 0.35%
- Category 1.00%
- Yield
- 0.35%
- Trailing distributions
- 3Y CAGR
- 25.9%+12.3%
- Category 13.5%
- 5Y CAGR
- 3.6%+1.7%
- Category 1.9%
Loading NAV history…
State Street SPDR S&P Biotech ETF
Calendar-year returns
Fund only: no comparison series covers this fund's history.
Risk statistics
Five years of daily closes. Risk-free rate 4% a year.
- Standard deviation
- —
- Maximum drawdown
- —
- Sharpe ratio
- —
- Sortino ratio
- —
- Beta
- —
- Alpha
- —
- R²
- —
- Information ratio
- —
- Upside capture
- —
- Downside capture
- —
- Tracking error
- —
Holdings
The 10 largest positions make up 15.6% of the fund.
Top holdings
| Ticker | Holding | Weight |
|---|---|---|
| MRNA | Moderna Inc | 2.81% |
| TWST | Twist Bioscience Corp | 1.89% |
| APGE | Apogee Therapeutics Inc | 1.50% |
| KYMR | Kymera Therapeutics Inc Ordinary Shares | 1.40% |
| HALO | Halozyme Therapeutics Inc | 1.39% |
| NTRA | Natera Inc | 1.37% |
| PRAX | Praxis Precision Medicines Inc Ordinary Shares | 1.34% |
| ORKA | Oruka Therapeutics Inc | 1.33% |
| RVMD | Revolution Medicines Inc Ordinary Shares | 1.31% |
| TVTX | Travere Therapeutics Inc Ordinary Shares | 1.30% |
Portfolio valuation
Weighted averages of what the fund holds.
- P/E
- —
- P/B
- 4.9
- P/S
- 8.2
- P/CF
- —
Sector allocation
Share of the equity the fund holds.
- Health care99.3%
- Financial services0.7%
Asset mix
- Stocks100.0%
- Cash0.0%
ETF details
- Issuer
- State Street Investment Management
- Category
- Equity · Health
- Ticker
- XBI
- Exchange
- NYSE Arca
- Inception
- 31 Jan 2006 (20.6 years)
- Structure
- Exchange Traded Fund
- Expense ratio
- 0.35% (category 1.00%)
- Holdings turnover
- 71% (category 51%)
- Distribution yield
- 0.35%
- Beta, 3 years
- 1.12
- Total net assets
- $11.4B
Prices and returns as of 11 Sept 2026; total return with distributions reinvested, before brokerage and taxes. Not investment advice.
Other health ETFs
Other ETFs in the Health category.
- IBB · iShares Biotechnology ETFiShares · $10.5B · ER 0.44%5Y 3.5%
- IXJ · iShares Global Healthcare ETFiShares · $4.3B · ER 0.38%5Y 4.5%
- IYH · iShares U.S. Healthcare ETFiShares · $3.9B · ER 0.37%5Y 5.2%
- FHLC · Fidelity MSCI Health Care Index ETFFidelity Investments · $3.5B · ER 0.08%5Y 5.1%
- IHI · iShares U.S. Medical Devices ETFiShares · $3.5B · ER 0.37%5Y -4.7%
- FBT · First Trust NYSE Arca Biotechnology Index FundFirst Trust · $2.9B · ER 0.55%5Y 9.2%