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ALPSHealthSBIO · NYSE Arca

ALPS Medical Breakthroughs ETF (SBIO)

Price
$54.87
—30 Oct 2026
Assets
$211.6M
Total net assets
Expense ratio
0.50%
Category 1.00%
Yield
0.00%
Trailing distributions
3Y CAGR
33.3%+11.8%
Category 21.5%
5Y CAGR
4.3%+0.2%
Category 4.1%
Loading NAV history…
ALPS Medical Breakthroughs ETF

Calendar-year returns

Fund only: no comparison series covers this fund's history.

Risk statistics

Five years of daily closes. Risk-free rate 4% a year.

Standard deviation
—
Maximum drawdown
—
Sharpe ratio
—
Sortino ratio
—
Beta
—
Alpha
—
R²
—
Information ratio
—
Upside capture
—
Downside capture
—
Tracking error
—
Trailing returns compared with benchmark
Period1M3M6MYTD1Y3YCAGR5YCAGR10YCAGRLaunchCAGR
ETF-5.9%-13.4%+2.5%+7.1%+22.8%+33.3%+4.3%+10.4%+7.7%
Health average3.6%9.9%23.0%20.4%28.8%21.5%4.1%10.8%11.6%
Difference-9.5%-23.3%-20.5%-13.3%-6.1%+11.8%+0.2%-0.4%-4.0%

Holdings

The 10 largest positions make up 30.2% of the fund.

Top holdings

Largest holdings by weight
TickerHoldingWeight
CGONCG Oncology Inc3.94%
TVTXTravere Therapeutics Inc Ordinary Shares3.48%
ORKAOruka Therapeutics Inc3.45%
DFTXDefinium Therapeutics Inc Ordinary Shares3.20%
MANEVeradermics Inc3.17%
DNTHDianthus Therapeutics Inc3.08%
EWTXEdgewise Therapeutics Inc2.76%
RLAYRelay Therapeutics Inc Ordinary Shares2.48%
IDYAIDEAYA Biosciences Inc2.32%
AMLXAmylyx Pharmaceuticals Inc2.29%

Portfolio valuation

Weighted averages of what the fund holds.

P/E
—
P/B
3.4
P/S
7.1
P/CF
—

Sector allocation

Share of the equity the fund holds.

100.0%Health care
  1. Health care100.0%

Asset mix

  • Stocks100.0%
  • Cash0.0%

ETF details

Issuer
ALPS
Category
Equity · Health
Ticker
SBIO
Exchange
NYSE Arca
Inception
30 Dec 2014 (11.8 years)
Structure
Exchange Traded Fund
Expense ratio
0.50% (category 1.00%)
Holdings turnover
58% (category 51%)
Distribution yield
0.00%
Beta, 3 years
0.92
Total net assets
$211.6M

Prices and returns as of 30 Oct 2026; total return with distributions reinvested, before brokerage and taxes. Not investment advice.

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